Multifunctional Up-conversion Luminescent Platforms Based on LiYF4:Tm3+,Yb3+@SiO2 nanoparticles decorated with iridium(III) complexes as agents in sensing and photodynamic therapy

• Grant number: 22/14042-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2023
• Status: Discontinued
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Sergio Antonio Marques de Lima
• Grantee: Renan Caike Silva
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated scholarship(s): 24/21506-4 - Design of theranostic agents based on upconversion nanoparticles with core-multi-shell architectures of LiREF4 doped with lanthanides(III) and grafted with luminescent iridium(III) complexes, BE.EP.DR

Abstract

The search for efficient and minimally invasive treatments against cancer unites and motives researchers from different areas of science. One of these strands is the development of multifunctional luminescent theranostic platforms as agents in photodynamic therapy (PDT) combining luminescent sensing for diagnosis and treatment through reactive oxygen species (ROS). In this sense, we will study the functionalization of LiYF4 upconversion nanoparticles (UCNPs) doped with Tm3+ and Yb3+ ions, coated with SiO2 and aminofunctionalized with APTES, at the end the UCNPs will be grafted with luminescent iridium(III) complexes. This LiYF4:Tm3+,Yb3+@SiO2-NC-[(L1)[Ir(C^N)2] platform is capable of converting the excitation in the near infrared (NIR) into ultraviolet light, a region in resonance with the absorption of the complexes of iridium(III) and take advantage of the ROS generation triggered by the predominantly 3LC-1,3MLCT triplet emission from the Ir(III) complex in the presence of 3O2. The use of this luminescent platform is also motivated by the sensing of dissolved oxygen and the versatility of bioconjugation to the nanoparticle, providing specific cellular targets. Therefore, in the first part of this project we intend to synthesize, characterize and test as photosensitizers a series of 6 (six) new heteroleptic iridium(III) complexes [Ir(C^N)2(L1), where C^N = ppy, fppy and bzq; L1 = pzdc and pdc. The second part intends to synthesize and characterize the upconversion nanoparticles decorated with luminescent iridium(III) complexes, developing a multifunctional platform aiming application in photodynamic therapy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, RENAN C.; CANISARES, FELIPE S. M.; SARAIVA, LEONARDO F.; PIRES, ANA M.; LIMA, SERGIO A. M.. Featuring long-lifetime deep-red emitting iridium^III complexes with high colour purity: insights into the excited state dynamics from spectroscopic and theoretical perspectives. DALTON TRANSACTIONS, v. 53, n. 12, p. 12-pg., 2024-02-28. (19/26103-7, 22/14042-6, 22/08409-4, 23/05718-9)