Intermittent hypoxia in Parkinson's disease: Acute effect on locomotion, sleep quality and blood biomarkers

• Grant number: 22/09235-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2023
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Fabio Augusto Barbieri
• Grantee: Murilo Henrique Faria
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated scholarship(s): 24/00327-4 - ACUTE EFFECT OF INTERMITTENT HYPOXIA ON INTERMUSCULAR COHERENCE ON GAIT IN PEOPLE WITH PARKINSON'S DISEASE, BE.EP.MS

Abstract

Parkinson's disease (PD) is characterized by motor dysfunctions, such as gait, and non-motor dysfunctions, such as sleep and metabolism, which impact the quality of life. Thus, determining interventions that optimize the treatment of PD is essential to alleviate the effects of these disorders and the disease progression. However, important gaps are observed in the literature related to efficient interventions that do not have adverse effects, such as drug treatment. Intermittent normobaric hypoxia (IH), although little studied in PD has gained visibility in recent years, revealing improvement in systemic sensitivity and motor and non-motor symptoms. This intervention has shown positive effects on iron homeostasis and mitochondrial function, which are essential for neural survival, may be a promising strategy to improve gait, sleep and metabolism in people with PD. Therefore, the objective of this research project is to investigate the acute adaptations induced by IH on gait, sleep quality, and blood biomarkers in people with PD. Two studies will be carried out: i) systematic review: the body of knowledge about the responses induced by exposure to hypoxia in people with PD will be reviewed; ii) experimental study: people with PD and neurologically healthy will perform two conditions of oxygen availability: IH - the oxygen concentration will alternate: 5min in hypoxia and 5min in normoxia; and normoxia - there will be no change in oxygen concentration (total of 35min under both conditions). Gait (kinematic and muscle parameters), sleep quality (through actigraphy and questionnaires), and blood biomarkers (BDNF, IL-6, and iron concentration) will be evaluated before, immediately after and 24 h after the conditions. Therefore, we hope to significantly contribute to the application of IH in rehabilitation programs for people with PD.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, ELISA DE CARVALHO; FILHO, CARLOS AUGUSTO KALVA; ESTEVES, ANDREA MACULANO; GUELFI, ERICA TARDELLI NEVES; VIULLERME, NICOLAS; BARBIERI, FABIO AUGUSTO. Sleep "ON", sleep better! Positive effects of levodopa on sleep behaviour in people with Parkinson's disease. Journal of Sleep Research, v. 33, n. 6, p. 8-pg., 2024-05-19. (22/02971-2, 22/09235-0)

KALVA-FILHO, CARLOS A.; FARIA, MURILO HENRIQUE; PAPOTI, MARCELO; BARBIERI, FABIO AUGUSTO. Acute and cumulative effects of hypoxia exposure in people with Parkinson's disease: A scoping review and evidence map. PARKINSONISM & RELATED DISORDERS, v. 118, p. 9-pg., 2024-01-04. (22/02971-2, 22/09235-0)