| Grant number: | 23/06629-0 |
| Support Opportunities: | Scholarships abroad - Research |
| Start date: | August 25, 2023 |
| End date: | September 24, 2023 |
| Field of knowledge: | Biological Sciences - Immunology - Cellular Immunology |
| Principal Investigator: | Caroline Marcantonio Ferreira |
| Grantee: | Caroline Marcantonio Ferreira |
| Host Investigator: | Anne Sperling |
| Host Institution: | Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil |
| Institution abroad: | University of Virginia (UVa), United States |
| Associated research grant: | 21/06751-4 - Deciphering the immune mechanism of increased airway allergic disease in menopause, AP.JP2 |
Abstract Asthma has been extensively studied in women of reproductive age, while the menopausal age range has been less studied. Among women over 50 years old of age, menopause can either coin-cide with the onset of asthma, or in women with pre-existing asthma, be associated with the worsening of symptoms. Recently, our lab published findings showing that the re-exposure of ovariectomized (OVx) allergic mice to antigen exacerbates lung inflammation and decreases air-way function, however the mechanisms involved are not clear. In addition, preventive but not therapeutic supplementation with acetate-producing bacterium, Bifidobacterium longum 51A, is able to prevent the increased recall response and airway inflammation in OVx allergic mice. Short chain fatty acid (SCFA), such as acetate, has been implicated in the impaired ability of dendritic cells (DCs) to promote Th2 cell effector function and increase levels of T-regulatory (Tregs) cells. However, the mechanisms by which these probiotics or SCFAs can prevent exacerbation of aller-gic airway inflammation in OVx mice needs to be identified. Recently, allergen-specific resident memory T cells (TRM) have been found to accumulate after HDM exposure and mediate experi-mental asthma symptoms upon re-challenge. We show in this proposal preliminary data that tran-scription factor, IRF4+, in CD11c+ conventional type 2 DC cells (cDC2) is necessary for the de-velopment of Th2 differentiation. Interestingly, estrogen receptor signaling promotes dendritic cell differentiation by upregulating IRF4. Our central hypothesis is that menopause induces exac-erbation of pre-existing asthma through induction of IRF4+ cDC2s and Th2-skewed TRM cells, and that short chain fatty acid will mute this response. Understanding the mechanisms by which the decline of female sex hormones promotes the worsening of asthma is key to the development of new targets for therapeutics. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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