Screening of a library of synthetic and natural compounds for antibacterial activity to ESKAPE group bacterial strains

• Grant number: 23/07721-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2023
• End date: July 31, 2024
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Pedro Henrique Torquato dos Santos
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 19/17721-9 - The role of Chemistry in holobiont adaptation, AP.TEM

Abstract

Antimicrobial'sresistance is a widespread feature in pathogenic bacteria to humans and other animals, representing a worldwide public health problem(Ogboluet al., 2020; Mancuso et al.,2021; BenkQet al., 2020). Infections caused by the so called antimicrobial resistant (AMR) bacteria are difficult to treat with available antimicrobials (Dadgostar P., 2019; Velazquez-Meza et al., 2022). A recent report ofthe IACG (Interagency Coordination Group on Antimicrobial Resistance) draws attention to the fact that drug-resistant bacteria are currently responsible for approximately700,000 annual deaths, a situation that in the most pessimistic scenarios could increase to 10 million annual deaths by 2050.This scenario is no longer a fictitious one, since a recent report estimated that in 2019, resistant bacteria were associated with 4.95 million deaths, including 1.27 million deaths that were directly attributable to bacterial AMR(Antimicrobial resistance Collaborators, 2022). Therefore, the searching and description of new antimicrobial drugs is urgent needed to control these infections.