Metal complexes containing thiosemicarbazones derived from functionalized vanillin: synthesis, characterization and evaluation of antiproliferative activity against breast cancer cell lines

• Grant number: 23/12153-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2023
• End date: September 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Adelino Vieira de Godoy Netto
• Grantee: Danielle Cristina Oliveira Mascaro
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Breast Cancer (BC) is the most common type of non-cutaneous cancer and the second leading cause of cancer death among women worldwide. Breast tumors are characterized by differences in behavior, biological evolution and therapeutic responses. Due to its heterogeneity and complexity, the discovery of new molecules to increase our available arsenal in the war against CM is an urgent and challenging task. The present proposal aims at the synthesis and evaluation of the antiproliferative activity mediated by complexes of the general formula [M(X-VTSC)2] and [PdCl(PPh3)(X-VTSC)] (M=Ni(II), Pd(II); Pt(II); R-vTSC = thiosemicarbazonates derived from O-functionalized vanillin with N-ethylpiperidine and N-ethylmorpholine groups) against CM cells of different phenotypes. The characterization of the complexes will be carried out based on the results obtained by the techniques of elemental analysis, IR and NMR spectroscopy, ESI/MS spectrometry, and single crystal X-ray diffraction. The cytotoxic effects of stable compounds in solution will be evaluated against CM cell lines of different phenotypes MCF7 (dependent hormone), SKBR3 (HER2 +) and MDA-MB-231 (triple negative) and against non-tumor breast cells MCF- 10A, aiming to establish some structure-activity relationships. The most promising compounds will be selected for further investigation of their interaction with human albumin (HSA) and ct-DNA.