SYNTHESIS AND CHARACTERISATION OF Pd(II) COMPLEXES CONTAINING TIPPER-TYPE AND PHOSPHINE-TYPE THIOSEMICARBAZONES: INVESTIGATION OF INTERACTIONS WITH BIOMOLECULES AND CYTOTOXICITY

• Grant number: 24/04136-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2024
• End date: May 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Fillipe Vieira Rocha
• Grantee: Letícia Rodrigues Jacinto
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Cancer is a term used to describe a group of diseases that can affect any part of the body, one of the main characteristics of which is rapid growth beyond what is considered normal. Approximately one in six people die from various forms of the disease, making it the second leading cause of death worldwide. To reduce the mortality rate, various treatments are used to combat the diseases, including chemotherapy. Among the chemotherapeutic agents approved for clinical use worldwide, cisplatin and its derivatives stand out, but they have various side effects and suffer from cellular resistance. One way of trying to mitigate these harms is to modify the structure of the complex's molecular backbone by inserting different ligands into its coordination sphere, thus allowing the compound to alternate how it acts in the body. To this end, this project aims to synthesise four new palladium(II) complexes containing thiosemicarbazones of the pincer and phosphine type, with the following general formulae PdHL1PTA, PdHL2PTA, PdHL3PTA and PdHL4PTA. All compounds will be characterised using NMR, IR, UV-Vis, mass spectrometry and elemental analysis techniques. The possible interaction of the complex with DNA and toposimoresis will be evaluated by experiments such as competition with ethidium bromide, viscosity, electrophoretic mobility test and electronic absorption spectroscopy in the UV-Vis region. Promising complexes will be tested for their ability to affect cell viability in cytotoxicity assays against tumour and non-tumour cell lines.