Integrated Synthesis of Butenolides in Continuous Flow Regime.

• Grant number: 23/15576-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2023
• End date: November 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Júlio Cezar Pastre
• Grantee: Lucas Gonçalves Rocha
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 21/06661-5 - Enabling technologies for the sustainable chemical synthesis of platform molecules, new chemicals and bioactive compounds, AP.BIOEN.JP2

Abstract

The generation and use of reactive intermediates are well suited to continuous flow processing due to the ability to scale up reactions, confine toxic and hazardous reagents, and allow the heating of solvents beyond their respective boiling points. In previous work, we explored the chemistry of acyl ketenes, generated from 2,2,6-trimethyl-4H-1,3-dioxin-4-one (TMD) under continuous flow reaction conditions and the system developed was capable of enabling a wide range of applications of these acylketene intermediates. To continue this work, and explore the application of the conditions developed, we propose in this subproject the synthesis of libraries of butenolides and cadiolides in an integrated process under reaction conditions in a continuous flow regime.