| Grant number: | 23/14929-3 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | January 01, 2024 |
| End date: | August 31, 2025 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Cesar Seigi Fuziwara |
| Grantee: | Antonio Tarelo Freitas de Oliveira |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 19/17282-5 - Transcriptional and post-transcriptional control in aggressive cancer and metastasis, AP.JP |
Abstract Thyroid cancer is the most common malignancy of the endocrine system and generally has a good clinical prognosis with surgical treatment and radioiodine therapy. However, a certain fraction of cases are aggressive and refractory to treatment. Mutations in the promoter of the TERT gene (TElomerase Reverse Transcriptase) are highly prevalent in aggressive thyroid carcinomas, especially in anaplastic carcinoma, a lethal histotype of thyroid cancer. These mutations in the promoter region lead to overexpression of TERT and correlate with clinicopathological features such as increased invasion, recurrence and death. Recent studies indicate that the role of TERT in cancer is not limited to telomere maintenance, being also a potential modulator of gene expression in pathways such as NFkB and Wnt/²-catenin. However, its role in thyroid cancer is still unclear. Therefore, the aim of this study is to investigate the role of TERT reactivation in the biology of aggressive thyroid cancer. To do so, we will use methodologies to block TERT expression/function such as overexpression of microRNAs, CRISPR interference (dCas9-KRAB) and pharmacological blockade. | |
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