Synthesis of natural di- and triterpenes through selective oxidation reactions of C-H bonds

• Grant number: 23/13162-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2024
• End date: February 28, 2029
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Emílio Carlos de Lucca Júnior
• Grantee: Lucas Dias Pires Gonçalves
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/04837-6 - Oxidation of aliphatic C-H bonds catalyzed by transition metals, AP.JP

Abstract

This Research Project proposes to investigate methodologies to selectively oxidize C-H bonds, using complex natural products as platforms to obtain compounds with higher oxidation state. Due to the ubiquity of these bonds in organic molecules, different procedures have been developed and enhanced in order to selectively oxidize synthetically interesting positions to obtain new compounds with different physical and chemical properties. In this context, we intend to use emerging methodologies to synthetize natural di- and triterpenoids, targeting strategically important positions to obtain derivatives with higher oxidation state. (AU)