Evaluation of the sedative effects of midazolam associated or not with butorphanol after intranasal administration in true parrots (Amazona aestiva)

• Grant number: 23/16291-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2024
• End date: July 31, 2025
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Silvia Renata Gaido Cortopassi
• Grantee: Maria Eugênia Furtado Walther
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The true parrot (Amazona aestiva) is a bird belonging to the Psittaciformes family that occurs naturally in the Northeast, Center-West, Southeast and South regions of Brazil. Due to its social characteristics, coloring, speaking ability and easy adaptation to different environments, it has become a species traditionally bred as a pet not only in Brazil, but throughout the world, being among the most popular birds kept in captivity. Consequently, it is also among the birds most attended to in the veterinary clinical-surgical routine. In this scenario, sedation is important as a tool to ensure adequate and safe clinical evaluation, carrying out complementary exams and collecting biological samples. The present study therefore aims to evaluate the sedative effect and cardiorespiratory impact of midazolam and butorphanol in true parrots, when administered intranasally. The animals included in the experiment will come from the Wild Animal Conservation Management Center (CeMaCas) of the Wildlife Division of the City of São Paulo. In a crossover, randomized and blind design, 10 individuals will receive midazolam (GM - 2 mg/kg), midazolam-butorphanol (GMB - 2 mg/kg each) or saline solution (GCON - 0.3mL/kg), considering, at least , 15 days of interval between groups. The cardiorespiratory effects, latency period, quality of sedation, time and quality of recovery will be evaluated. In this way, we intend to evaluate the contribution of intranasal butorphanol to the sedation and recovery of true parrots, when associated with midazolam.