The impact of cycles of fat mass gain and loss on systemic metabolism and energy balance in an experimental model of diet-induced obesity

• Grant number: 24/01567-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2024
• End date: February 28, 2025
• Field of knowledge: Biological Sciences - Biology
• Principal Investigator: Licio Augusto Velloso
• Grantee: Evellin da Silva Matai
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

According to the World Health Organization, obesity is defined as an excessive accumulation of body fat that poses a health risk to the individual. The prevalence of obesity has been increasing worldwide, reaching alarming levels, with projections indicating that more than half of the population in some developed countries will be diagnosed with obesity in less than 10 years. In Brazil, obesity is also on the rise, particularly among adults and young people. Although the country's public healthcare system is relatively good compared to other developing nations, challenges remain. According to the Global Preparedness Classification, Brazil has 43.7% of premature deaths caused by diseases associated with obesity, such as type 2 diabetes, heart diseases, cancer, and depression. Preventing and treating this condition requires substantial financial investments. However, despite these efforts, the prevalence of obesity continues to rise, and the treatment of obesity is challenging due to its recurrence and refractoriness. This study aims to assess the effects of multiple cycles of weight gain and loss in an animal model of diet-induced obesity, with the goal of better understanding the mechanisms behind obesity recurrence. The study will also evaluate metabolic parameters and the control energy balance in these animals. It seeks to deepen our understanding of obesity and its challenges, particularly insights that may inform more effective prevention and treatment strategies.