The use of visual psychophysical and electrophysiological tests in the identification of biomarkers of progression in Alzheimer's Disease

• Grant number: 24/00163-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2024
• End date: March 31, 2026
• Field of knowledge: Humanities - Psychology - Physiological Psychology
• Principal Investigator: Dora Selma Fix Ventura
• Grantee: Luiz Claudio Portnoi Baran
• Host Institution: Instituto de Psicologia (IP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/00191-0 - Mechanisms, genetics and performance of the visual system: clinical research in humans and animal experiments, AP.TEM

Abstract

Alzheimer's Disease (AD) is a chronic and progressive neurological condition, carachterized by processes that lead to neurodegeneration with cognitive loss and death. AD has gradual progression, resulting in memory loss, loss of cognitive capabilities and behavioral alterations that includes social interaction alterations, sleeping disturbances and circadian rhytm dysfunction. Diagnostic difficulties demand new investigative techniques that can reveal biomarkers, especially in early stages. Visual alteration is a common and well documented symptom of AD. The present project uses psychophysical and electrophysiological functional tests for the visual evaluation of DA and Mild Cognitive Compromise subjects in the search for reliable biomarkers.