Evaluation of the efficacy of parasite treatment and toxicity with nanoparticles containing levadasisol

• Grant number: 24/05994-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2024
• End date: December 31, 2025
• Field of knowledge: Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
• Principal Investigator: Patrick Mathews Delgado
• Grantee: Nathan Garcez Silva
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 22/12376-4 - Development of parasite treatment in fish with nanoparticles: a technology-applied approach, AP.JP

Abstract

A high-potential strategy to enable pathogen treatments in aquaculture is the development of nanomaterial carriers for drug delivery. In this study it will bea nanoparticle with mucoadhesive and pH-responsive properties is produced by the conjugation between the biopolymers chitosan and alginate, which originate a colloidal polyelectrolyte complexas a result of electrostatic interaction due to their opposite charges in solution. The nanoparticle will be developed to encapsulate the anthelmintic drug levadasisol andIts effectiveness in parasite treatment will be studied, as well as possible toxicity will be evaluated.