Development of parasite treatment in fish with nanoparticles: a technology-applied approach

• Grant number: 22/12376-4
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: September 01, 2023
• End date: August 31, 2028
• Field of knowledge: Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
• Principal Investigator: Patrick Mathews Delgado
• Grantee: Patrick Mathews Delgado
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Fabienne Audebert ; Marcos Tavares Dias ; Maurício Laterça Martins ; Omar Mertins ; Reinaldo José da Silva
• Associated research grant(s): 24/02665-4 - Macromolecular functionalization for boosting antiparasite-drugs administration to fish cultures, AP.R SPRINT
• Associated scholarship(s): 25/02188-4 - Study of the effectiveness of a nanoparticle carrying praziquantel in treatment of monogenetics and digenetics and effects on parameters blood and tissue of tambaqui fry, BP.MS; 24/00115-7 - Levamisole-carrying nanoparticle for treatment of acanthocephalans in fingerlings and juveniles of tambaqui Colossoma macropomum from fish farms, BP.DR; 24/05235-0 - Nanoparticle carrying albendazole for the treatment of monogenean infestation in tilapia fry from fish farms, BP.MS; + associated scholarships 24/05688-5 - Development of nanoparticles for carrying the drug albendazole and application studies in tilapia, BP.IC; 24/05994-9 - Evaluation of the efficacy of parasite treatment and toxicity with nanoparticles containing levadasisol, BP.IC; 23/11142-2 - Development of parasite treatment in fish with nanoparticles: a technology-applied approach, BP.JP - associated scholarships

Abstract

Aquaculture is expanding in Brazil and in the world and pathologies associated with the increase in fish production have been growing proportionally, which highlights the need to invest in new treatment technologies aimed at quality and added value. In this sense, this project aims at the application development of biocompatible and biodegradable nanoparticles as drug carriers for oral administration in consumption fish for parasitic treatments. The nanoparticles will be developed with biopolymers providing: effective encapsulation of antiparasitic drugs; high palatability for oral administration to fish, improving efficiency, minimizing losses and avoiding water pollution; protection against drug degradation in gastric juice; reduction or elimination of toxicity; mucoadhesion in the intestinal mucosa, optimizing drug release in the intestine and achieving high bioavailability, resulting in efficient treatments and at the same time reducing the chances for pathogen resistance generation. Physicochemical, in vitro and in vivo studies will be carried out aiming at the development of nanotechnology in the treatment of parasites that affect the production of tilapia (Oreochromis niloticus) and tambaqui (Colossoma macropomum). The project aims at the effective application of a parasite treatment system with commercial appeal and potential application in aquaculture. Fundamentally, the project proposes the use of nanotechnology as a new strategy in fish production. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOTA, MARIA E. B. P.; MATHEWS, PATRIK D.; MILANIN, TIAGO; MERTINS, OMAR; PAIVA, FERNANDO; OLIVEIRA, CARINA E.; TAVARES, LUIZ E. R.. Phylogenetic position inferred on SSU rDNA sequence gene and description of a new parasitic cnidarian (Endocnidozoa: Myxobolidae) infecting Markiana nigripinnis (Teleostei: Stevardiinae) from a small marginal lake floodplain, Brazil. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, v. 13, n. 2, p. 9-pg., 2024-06-01. (22/12376-4)

MADRID, RAFAEL R. M.; MATHEWS, PATRICK D.; PRAMANIK, SHREYA; MANGIAROTTI, AGUSTIN; FERNANDES, RODRIGO; ITRI, ROSANGELA; DIMOVA, RUMIANA; MERTINS, OMAR. Hybrid crystalline bioparticles with nanochannels encapsulating acemannan from Aloe vera: Structure and interaction with lipid membranes. Journal of Colloid and Interface Science, v. 673, p. 13-pg., 2024-06-14. (21/00971-2, 22/12376-4)