Sodium Channel Nav1.8 as a therapeutic target to treat arrhythmias in pulmonary hypertension and Fabry disease

• Grant number: 24/06444-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2024
• End date: May 31, 2026
• Field of knowledge: Biological Sciences - Pharmacology
• Principal Investigator: Danilo Roman Campos
• Grantee: Michael Ramon de Lima Conceição
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 20/14635-1 - Modeling of monogenic diseases for physiopathological studies and pharmacological tests using specialized cells derived from iPSCs, AP.TEM

Abstract

Cardiovascular diseases (CVD) are the leading cause of death worldwide. According to the World Health Organization, more than 18.6 million human beings globally have died as a result of cardiovascular diseases in the year 2022. Cardiac arrhythmias are the major cause of death in patients with CVD. Recent evidence indicates that SCN10A/NaV1.8 is associated with some types of cardiac arrhythmias. Therefore, the proposed study will investigate the role of NaV1.8 channels in the arrhythmias observed: 1) in the animal model of pulmonary hypertension (PH) induced by monocrotaline; 2) in the in vitro model of the heart disease of Fabry disease through genetic manipulation, using cardiomyocytes derived from pluripotent stem cells. In the end, our project will provide evidence for the proposal of a new therapeutic target for the treatment of cardiac arrhythmias observed in patients with Fabry disease and pulmonary hypertension.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONCEICAO, MICHAEL RAMON DE LIMA; TEIXEIRA-FONSECA, JORGE LUCAS; ORTS, DIEGO JOSE BELATO; NASCIMENTO, DANIELLA SANTOS; DANTAS, CACIA OLIVEIRA; DE VASCONCELOS, CARLA MARIA LINS; SOUZA, DIEGO SANTOS; ROMAN-CAMPOS, DANILO. Exploring the interplay between extracellular pH and Dronedarone's pharmacological effects on cardiac function. European Journal of Pharmacology, v. 983, p. 11-pg., 2024-09-12. (24/06444-2, 22/07256-0, 22/14133-1, 21/05584-7, 20/14635-1)