Association Between Clinical Profile, Comorbidities, and Serum Levels of TNF-alpha and IL-6 in Patients from the ELLAMI Cohort: A Longitudinal Study

• Grant number: 24/06067-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2024
• End date: June 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Lucas Leite Cunha
• Grantee: Lucas Pinto Ribeiro
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Chronic Non-Communicable Diseases (NCDs) constitute illnesses with multiple causes and risk factors, characterized by a prolonged course, functional impairment, and diminished quality of life in individuals. In this context, there is evidence that systemic inflammatory markers, such as IL-6 and TNF-alpha, are associated with this low-grade and chronic inflammatory state, also known as "inflammaging" - a predictor of immunologically accelerated aging. In this scenario, there is a quest to better understand the immunobiological mechanisms of NCDs, evaluating a possible correlation between clinical and laboratory predictor variables and relevant clinical outcomes. For this purpose, a prospective cohort study is proposed, utilizing data from participants of the internal medicine outpatient clinic of the Academic League of Internal Medicine (ELLAMI), at the Federal University of São Paulo/Paulista School of Medicine, for statistical analysis, integrating demographic, clinical, and molecular information that will be collected.