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Evaluation of possible structural and functional changes in the auditory system nuclei in a rodent model of Parkinson's Disease induced by 6-hydroxy-dopamine (6-OHDA) injection.

Grant number: 24/02987-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date: June 01, 2024
End date: December 31, 2024
Field of knowledge:Health Sciences - Speech Therapy
Principal Investigator:Ariadiny de Lima Caetano
Grantee:Maria Fernanda Batista de Oliveira
Host Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil

Abstract

Neurodegenerative disorders constitute a distinct group of various chronic diseases that generate several complications throughout their development, affecting a population of over 30 million worldwide. Parkinson's Disease (PD) is characterized by a chronic progressive neurodegenerative condition resulting from the degeneration of dopaminergic neurons located in the substantia nigra of the midbrain and the accumulation of Lewy bodies. Patients with PD exhibit motor symptoms such as resting tremor, muscular rigidity, bradykinesia, hypokinesia, and alterations in posture and balance, in addition to non-motor symptoms such as changes in sleep, depression, dysfunction of the autonomic nervous system, memory impairment, and, more recently, hearing alterations appearing before motor symptoms in PD. Central auditory processing involves the efficiency and effectiveness of auditory information processing by the central nervous system. Literature data have shown a relationship between the increased incidence of dementia and patients who already had decreased hearing capacity. Considering the motor and non-motor alterations in PD, and that hearing alterations have recently been included as a new non-motor symptom, the objectives of this project are to evaluate whether the injection of 6-hydroxydopamine (6-OHDA) into the striatum (CPu) could cause structural and functional changes in the nuclei that make up auditory processing and to correlate the findings with behavioral changes.

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