Comparative Analysis Between Angiography and Intracoronary Ultrasound for Determining the Luminal Diameters of the Left Coronary Artery Trunk

• Grant number: 24/04862-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2024
• End date: April 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Pedro Alves Lemos Neto
• Grantee: Lucas Pilotto Ramos
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Introduction: The evaluation of obstructive coronary lesions by coronary angiography is essential in clinical practice, using visual methods or Quantitative Coronary Angiography (QCA). However, QCA is limited to assessing the arterial lumen, not directly reflecting the vessel's status. The equations of Murray, Finet, and Kassab, based on the law of conservation of mass, allow estimating the diameters of coronary branches. This study aims to explore the validity of these equations in patients with coronary atherosclerosis. General objective: To compare angiographic and Intravascular Ultrasound (IVUS) measurements in patients with coronary lesions, analyzing their validity regarding the equations of Murray, Finet, and Kassab. Study format: Single-center retrospective study in patients undergoing coronary angiography and IVUS in the left main coronary artery and its branches. Population: Patients undergoing angiography for clinical indications, with visually good-quality angiography of the left main coronary artery and its branches, and automated IVUS from the middle third of the distal branches to the ostium of the left main coronary artery. Outcomes: Comparison of luminal diameters measured by QCA and IVUS, stratified by degrees of atherosclerotic plaque, and their validity regarding the equations of Murray, Finet, and Kassab. Analytical Methodology: Analysis of angiographies with XAngio 7.3 software and IVUS with QIvus Research Edition 3.1. Equations will be applied to estimate branch diameters. Statistical analyses will include Pearson correlation and Bland-Altman tests. Risks and Benefits: Minimal risk of participant confidentiality breach, with data identification by codes. There is no direct benefit to participants, but they contribute to advancements in understanding the limitations of angiographic evaluation. Ethical and Regulatory Aspects: The study will be conducted according to Good Clinical Practices and ethical regulations. Informed consent will be obtained, and data confidentiality will be maintained. Student's Assignments: Student Lucas Pilotto Ramos will tabulate data, assist in image analysis, and contribute to the final manuscript.