Role of the peripheral chemoreceptors in development and maintenance of arterial hypertension.

• Grant number: 24/09071-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2024
• End date: July 31, 2025
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Benedito Honorio Machado
• Grantee: Italo da Costa Raulino
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 18/15957-2 - Astrocytic modulation on brainstem neurons involved with generation and control of sympathetic and respiratory activities in rodents submitted to hypoxia, AP.TEM

Abstract

In this project we will evaluate the role of arterial chemoreceptors in development and maintenance of hypertension in renal hypertensive rats (1 kidney-1 clip) and spontaneously hypertensive rats (SHR). The peripheral chemoreceptors (carotid bodies) will be removed before the development or during the maintenance of renal hypertension. In SHR the deactivation of peripheral chemoreceptors will be performed by chronic intermittent hiperoxia (CIH). The purpose of this projet is to evaluate the contribution of peripheral chemoreceptors in development and maintenance of renal and neurogenic hypertension due to the increase in their sensitivity with consequent increase in the sympathetic outflow and arterial pressure. Renal hypertensive rats (1R-1C) will be submittes to removal of carotid chemoreceptors while SHR will be submitted to CIH for 10 days. Baseline cardiovascular and respiratory parameteres and the responses to chemoreflex activation will be evaluated in conscious freely moving hypertensive rats 1R-1C and SHR. The results to be obtained will be important for a better understanding of the role of peripheral chemoreceptors in the generation of neurogenic hypertension and for a better evaluation of the possible use of hyperoxia as an strategy to reduce the peripheral chemoreceptors hyperactivity and consequent reduction in the sympathetic outflow and arterial pressure in SHR.