Development and characterization of PLA/Joncryl/Mg-based biotive composites

• Grant number: 24/10358-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2024
• End date: July 31, 2025
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Lidiane Cristina Costa
• Grantee: Lívia de Paula Rodrigues
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated research grant: 22/03157-7 - Additive manufacturing of bioactive composites for tissue engineering, AP.PNGP.PI

Abstract

Magnesium (Mg) is a biodegradable material that has outstanding performance, as well as being an essential element in the human body, partially stored in bone tissue. The presence of Mg in bone tissue promotes resistance and stimulates bone growth and has similar density and Young's modulus properties to human bone, then it a promising material for biomedical applications. However, in the bodily environment it undergoes rapid degradation and local alkalinization. Thus, controlling the rate of Mg degradation becomes a necessary strategy to allow the human body to progressively adjust or deal with the by-products of biodegradation. This can be done by incorporating the biomethal into a biocompatible/bioabsorbable polymer matrix. Poly(lactic acid), PLA, a polyester derived from lactic acid obtained from renewable sources, has stood out in this context. Conventional techniques for producing composites based on thermoplastic polymers/bioactive fillers generally employ high temperatures and shear rates which, in the presence of certain fillers, can lead to severe degradation of the polymer matrix. One way of recovering the molar mass of the polyester matrix is by adding chain extenders to the composition.