ENANTIOSELECTIVE PHOTOREDOX CATALYSIS IN BATCH AND CONTINUOUS FLOW SYSTEMS FOR THE SYNTHESIS OF ¿-AMINO ACID DERIVATIVES.

• Grant number: 24/12646-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2024
• End date: July 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Júlio Cezar Pastre
• Grantee: Rafael Alan Carvalho Souza
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 21/06661-5 - Enabling technologies for the sustainable chemical synthesis of platform molecules, new chemicals and bioactive compounds, AP.BIOEN.JP2

Abstract

In this research project, studies will be conducted on the stereoselective synthesis of ¿-amino acid derivatives through enantioselective photocatalysis, employing both batch and continuous flow systems. The objective is to obtain enantioenriched non-natural amino acids with potential biological and industrial applications. To achieve this, the proposed approach involves the reaction between ¿-imino esters and dihydropyridines (Hantzsch esters) in the presence of a rhodium(III) photocatalyst under visible light irradiation.