THE ROLE OF BRADYKININ RECEPTORS IN SPATIAL MEMORY, MOTOR CHANGES AND ANXIETY IN MICE SUBJECTED TO THE PARKINSON'S DISEASE MODEL

• Grant number: 24/03214-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2024
• End date: August 31, 2025
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Ariadiny de Lima Caetano
• Grantee: Anas Hussin
• Host Institution: Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP). Fundação Arnaldo Vieira de Carvalho. São Paulo , SP, Brazil

Abstract

Parkinson's Disease (PD) is defined as a progressive neurodegenerative pathology, presenting both motor symptoms (tremor, rigidity, bradykinesia) and non-motor symptoms (depression, sleep disturbances, deficits in memory and learning). This condition results from the degeneration of dopaminergic neurons, mainly in the substantia nigra pars compacta (SNpc), leading to a decrease in dopamine (DA) input through the nigrostriatal pathway in the caudate and putamen. Additionally, the disease is characterized by the presence of intraneuronal cytoplasmic inclusions containing aggregates of the ±-synuclein protein, known as Lewy Bodies (LB). Recent studies have demonstrated the involvement of the kallikrein-kinin system in Alzheimer's Disease (AD), showing an increase in kinins after beta-amyloid infusion in rats. Furthermore, the relationship between AD and kinin receptors indicates that B1R may be associated with neurodegeneration, while B2R may play a neuroprotective role. In light of this, investigating the involvement of the kallikrein-kinin system, with emphasis on B2 receptor activity, in other neurodegenerative conditions becomes relevant, especially considering its neuroprotective role. Therefore, this project aims to assess the influence of bradykinin receptors on spatial memory, motor alterations, and anxiety in mice subjected to the PD models