INTERACTIONS OF LIQUID BIOPSY AND PROTEOMICS - ANALYSIS OF PROSTATE CANCER TREATED WITH DOCETAXEL CARRYING NANOPARTICLES AND SUBJECTED TO AEROBIC PHYSICAL EXERCISE

• Grant number: 24/00096-2
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: October 01, 2024
• End date: July 31, 2025
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Giovana Rampazzo Teixeira
• Grantee: Allice Santos Cruz Veras
• Supervisor: Elin Gray
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: Edith Cowan University, Australia
• Associated to the scholarship: 20/16166-9 - DEVELOPMENT OF BIOTECHNOLOGY APPLIED TO PROSTATIC CARCINOMA WITH THE USE OF DOCETAXEL CHEMOTHERAPY CHARACTERISTIC NANOPARTICLES ASSOCIATED WITH AEROBIC PHYSICAL TRAINING, BP.DR

Abstract

The low level of physical activity associated with a sedentary modern lifestyle, coupledwith a high-fat diet, can lead to obesity and chronic systemic inflammation, promotingchanges in the immune system which may be related to the development of prostatecancer (PCa). Exercise is recognized for its potential role in reducing the risk of certaincancers, here we hypothesized that aerobic physical exercise positively modulates genesand protein involved in tumoral environment. Liquid biopsy has emerged as anattractive and promising strategy complementary to invasive tissue biopsy to guide PCadiagnosis, follow-up and treatment response. Liquid biopsy is employed to assessseveral body fluids biomarkers, including circulating tumor cells (CTCs), extracellularvesicles (EVs), circulating tumor DNA (ctDNA) and RNA (ctRNA). To test thishypothesis, prostatic tissues and serum of rats will be investigated. For this, we willobserve the liquid biopsy analysis between treated and non-treated groups.