Frequency of specific anti-HLA antibodies against the donor before the first dose of the anti-SARS-CoV-2 vaccine, the variables associated with their appearance and their association with renal function.

• Grant number: 24/14760-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jose Osmar Medina de Abreu Pestana
• Grantee: Pedro Henrique Moretti Pepato
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 21/13680-6 - Evaluation of SARS-CoV-2 infection and Coronavirus vaccine response in transplant recipients, dialysis patients, and health workers, AP.TEM

Abstract

It is known that in stable patients, without immunological events, the occurrence of new DSA (specific antibodies against the donor) is around 20% at the end of two years after transplantation. In addition to there being no studies in the Brazilian population in stable patients, it is not known what the risk factors are for the appearance of these antibodies in the Brazilian population, considering their peculiarities regarding the allocation system and standard immunosuppression.