The role of the hypoxia sensor HIF-1 alpha in podocytes: a link between cell metabolism and kidney injury.

• Grant number: 24/12992-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Isabella Bincoletto Trindade
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 23/07482-2 - Sensing extra and intracellular stressors by renal and immune cells: new insights into signal reception and transduction, and their relevance for understanding renal diseases, AP.TEM

Abstract

Chronic kidney disease (CKD) is a global public health problem and involves significant metabolic changes, which are important for the clinical evolution of the disease. Hypoxia and changes in the HIF-1 alfa pathway participate in the development and progression of different CKD models. Thus, understanding the metabolic parameters altered in CKD is of great importance for understanding the mechanisms involved in kidney injury and for the development of possible therapeutic targets that delay the progression of the disease. In the present study, we will evaluate the activation of HIF-1 alfa and its relationship with cellular metabolism in murine podocytes undergoing hypoxia. Our hypothesis is that the HIF-1 alfa pathway is a link between hypoxia-induced metabolic reprogramming and the development of inflammation and fibrosis. We intend with this project to obtain information that contributes to a better understanding of the complex mechanisms involved in DRC.