Analysis of biomarkers histopathological and behavioral of chronic exposure of mixtures of compounds Diflubenzuron and Piriproxifen in the Danio rerio experimental model

• Grant number: 24/14045-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2024
• End date: August 31, 2026
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Bruno Fiorelini Pereira
• Grantee: Alyne Monteiro Melo
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated research grant: 22/03094-5 - Project Zebratox: toxicological screening of larvicides of public and veterinary health importance, AP.PNGP.PI

Abstract

Initially, the selected fellow will be trained by the PhD fellow and will follow the analysis of their results and the calculations for the mixtures, thus understanding the core of their project. Afterwards, the fellow must perform chronic exposure to the mixtureof the selected compounds (phase shared between the master's fellows) and carry out the collection and histopathological analysis of gills,liver and gonads, this stage must be completed in the first 2 semesters of the master's degree.In the second half of the project, the scholarship holder will go to Profa's laboratory. Dr. Ana Carolina Luchiari to learn and perform behavioral tests for your project. This period will be extremelyimportance for the group, as it allows the exchange of students between participating laboratories. This stage must be completed in the third semester of the scholarship and the writing and compilation of data obtained throughout theexperimentation will be carried out in the last semester