Electrophysiological correlates of ASD in hiPSC-derived bioprinted neural constructs

• Grant number: 24/15729-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2024
• Status: Discontinued
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Marimélia Aparecida Porcionatto
• Grantee: Cristiano Soares Simões
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 18/12605-8 - Development of brain-on-a-chip microplataforms for in vitro modeling of the central nervous system, AP.TEM
• Associated scholarship(s): 25/23715-2 - Cell assembly detection in 3D bioprinted hiPSC neural constructs from Autism Spectrum Disorder patients, BE.EP.PD

Abstract

The study of in vitro cell culture together with the multielectrode arrays (MEA) technique has provided significant advances in our understanding of the neurobiological basis of several diseases, such as the Autism Spectrum Disorder (ASD). MEAs enable high precision recording of the electrical activity of neuronal populations, allowing for highly detailed assessment of action and local field potentials (LFPs) of complex cell networks. The spectral analysis of these signals allows us to infer communication mechanisms and to identify possible alterations in the neuronal activity underlying a neurological condition of interest.