Analysis of the Role of Colchicine in the Modulation of Interleukin 6 in Patients with Coronary Artery Disease (CAD).

• Grant number: 24/16404-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: September 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Carlos Nicolau
• Grantee: Enzo Kayano Gonçalves da Silva
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 23/10447-4 - Platelet aggregation: new therapeutic interventions, mechanisms and evaluation methods, with focus on high social impact diseases, AP.TEM

Abstract

Coronary artery disease (CAD) is a prevalent cardiovascular condition characterized by atherosclerosis and subsequent myocardial ischemia. Inflammatory processes, including the participation of pro-inflammatory cytokines such as interleukin-6 (IL-6), play a crucial role in the pathogenesis and progression of CAD. Colchicine, an anti-inflammatory drug, has shown a reduction in cardiovascular events and inflammation in patients with CAD. However, the precise mechanism of action of colchicine in modulating IL-6 levels and its impact on patients with CAD are still unclear. This research project aims to investigate the role of colchicine in modulating interleukin-6 in patients with CAD.