Synthesis of Ru-Pd Heterobimetallic Complexes as Bifunctional Catalysts for Tandem Suzuki-Miyaura/Transfer Hydrogenation

• Grant number: 24/15926-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: January 15, 2025
• End date: January 14, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Valdemiro Pereira de Carvalho Júnior
• Grantee: Douglas Henrique Nunes Santos
• Supervisor: Walter Baratta
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: Università degli Studi di Udine, Italy
• Associated to the scholarship: 22/12417-2 - Synthesis of new heterobimetallic complexes of RuII/NiII and RuII/PdII as multifunctional catalysts in the coupling of mechanistically distinct polymerization reactions, BP.DR

Abstract

Heterobimetallic Ru-Pd complexes will be synthesized to catalyze tandem Suzuki-Miyaura/transfer hydrogenation reaction of bromoaryl ketones with boronic acids and formic acid as hydrogen source. The project will be developed in three interconnected steps: initially, the Ru- and Pd-monometallic and Pd-Ru heterobimetallic complexes bearing the phenanthroline as bridging ligand will be synthesized. The second step will be addressed in evaluating the catalytic activity of the complexes for Suzuki-Miyaura of bromoaryl ketones and transfer hydrogenation of methylaryl ketones under thermal and photochemical conditions. Finally, the third step will focus on coupling the Suzuki-Miyaura and transfer hydrogenation reactions using bromoaryl ketones and boronic acids, followed by the addition of formic acid as a hydrogen source, employing assisted tandem catalysis for the synthesis of alcohol derivatives.