Study of the etiologies of changes in liver enzymes and canalicular canals in patients with systemic lupus erythematosus

• Grant number: 24/19332-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2024
• End date: November 30, 2025
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Emilia Inoue Sato
• Grantee: Rafaela Gomes Takatsu Paulista
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease,autoimmune, systemic and multifactorial etiology. Features a wide variety ofmanifestations that reflect the involvement of several organs, including the liver.Patients with SLE may present with changes in liver enzymes associated withexacerbation of the disease, viral infections, side effects ofmedications, alcohol use, autoimmune hepatitis (AIH), among othersconditions. Some of the chronic liver diseases in patients with SLE may beinitially asymptomatic, but can evolve with the appearance of severalsymptoms and even lead to a worsening of the prognosis. Therefore, it is indicatedmonitoring liver conditions in patients with SLE and, in the face ofenzymatic changes, research into possible etiologies for thetreatment of these patients.The main way to detect liver changes in patients withlupus is through the dosages of hepatic and canalicular enzymes, includingalanine aminotransferase (ALT), aspartate aminotransferase (AST), phosphatasealkaline (FA) and gammaglutamyl transferase (GGT). In this way, the present workaims to evaluate the most frequent etiologies of enzyme changeshepatic and canalicular in patients with SLE being followed up in theRheumatology at the University Hospital, Hospital São Paulo.