Development of a Lateral Flow Assay Coupled with Microneedles for Immunological Detection of Infectious Diseases

• Grant number: 24/21368-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2025
• End date: December 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Wendel Andrade Alves
• Grantee: Pedro Henrique Silva
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 22/14753-0 - Biosensing and delivery point-of-care technologies based on microneedles to improve healthcare testing and treatments, AP.TEM

Abstract

Microneedles (MNs) coupled with lateral flow assay (LFA) systems represent an emerging diagnostic technology with significant potential due to their low cost, ease of use, and minimally invasive nature. These systems allow the extraction of interstitial fluid (IFS) through micrometric channels, enabling the detection of biomarkers for infectious diseases with reduced pain and fewer side effects. This platform offers a rapid and portable method for immunologically detecting several pathogens responsible for acute infections, including leptospirosis. This approach aims to provide diagnostic accessibility, especially in resource-limited settings.