Cross -cultural adaptation and analysis of the psychometric properties of visual and olfactory assessment instruments in patients with migraine

• Grant number: 24/13121-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: February 01, 2025
• End date: August 31, 2026
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Débora Bevilaqua Grossi
• Grantee: Vitória Carolina Leonel
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Migraine is a neurological disease whose main manifestation is headache. However, the clinical picture also includes related to altered sensory perception, such as photophobia and osmophobia, which are symptoms of sensory hypersensitivity. Photophobia and osmophobia can impact the clinical presentation of migraine, as well as affect the quality of life and daily activities of patients. The use of objective tools to detect and measure the intensity of these factors is important for the clinical evaluation of the disease. Therefore, validated and reliable assessment instruments are essential. This study aims to translate into Brazilian Portuguese, cross -cultural adaptation, and validate the Leiden Visual Sensitivity Scale (L-VISS), Utah Photophobia Symptom Impact Scale version 2 (UPSIS-2), and Chemical Odor Sensitivity Scale (COSS) in individuals with migraine . For this purpose, adults with a diagnosis of migraine and at least one attack in the last month will be included. For the cultural adaptation process, 30 participants will be recruited, and for the validity and reliability phase of the tools, 60 participants will be included. Reliability will be assessed through a test-retest method, with an interval of 1 to 3 weeks, and internal consistency, intraclass correlation coefficient, and standard error of measurement will be calculated. Construct validity will be evaluated through hypothesis testing of the L-VISS and UPSIS-2 with the Pattern Glare Test and the questionnaires Headache Impact Test-6" (HIT-6"), 12-Item Short-Form Health Survey (SF-12 ), and 12-item Allodynia Symptom Checklist (ASC-12), and of the COSS with the 12-item Allodynia Symptom Checklist (ASC-12), Hospital Anxiety and Depression Scale (HADS), 12-Item Short-Form Health Survey (SF-12), and Headache Impact Test-6" (HIT-6"). Pearson correlation will be used for this analysis. It is expected that, at the end of this study, three valid and reliable tools will be available to the Brazilian population for clinical assessment of patients with migraine in both clinical and scientific settings.