EVALUATION OF NEW VACCINE CANDIDATES EXPRESSED BY INVASIVE FORMS OF MULTIDRUG-RESISTANT Staphylococcus aureus

• Grant number: 24/03222-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2025
• End date: February 29, 2028
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Thiago Rojas Converso
• Grantee: Brenda Vieira Ferreira
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil
• Associated research grant: 22/15111-1 - A novel selection and validadtion model for vaccine candidates against Staphylococcus aureus multi drug resistant, AP.R

Abstract

This study addresses the urgent need to develop effective vaccines against Staphylococcus aureus, a common pathogen that can cause anything from superficial infections to severe diseases. The resistance to multiple antibiotics increases the clinical challenge associated with this pathogen, emphasizing the importance of preventive strategies. The study proposes an innovative approach by integrating proteomic and transcriptomic analyses during the transition from biofilm to invasive phenotype. The process involves RNA isolation, library production, and sequencing, in collaboration with experts in proteomic analysis. The selection of target proteins is based on combined criteria, prioritizing exposed and conserved molecules. The study will also assess the immunogenic profile of candidates, recombinant production, and detailed characterization of the immune response. It is expected that this unique approach will significantly contribute to the development of more effective vaccine strategies against the challenging S. aureus.