Integration of Magnetomotive Ultrasound, Ultrafast Ultrasound Imaging and Ultrasound Localization Microscopy

• Grant number: 24/22214-7
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: May 25, 2025
• End date: May 24, 2026
• Field of knowledge: Physical Sciences and Mathematics - Physics
• Principal Investigator: Antonio Adilton Oliveira Carneiro
• Grantee: Ariane Franson Sanches
• Supervisor: Clement Papadacci
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Institut National de la Santé et de la Recherche Médicale (Inserm), France
• Associated to the scholarship: 22/12771-0 - Molecular imaging by magnetoacoustography using functionalized magnetic nanoparticles, BP.DD

Abstract

Magnetomotive Ultrasound (MMUS) is an emerging technique with great potential for theranostics application and molecular imaging, and consists of imaging magnetic nanoparticles (MNPs) displacement in a labeled tissue. This technique has been widely studied at the Group of Innovation and Medical Instrumentation in Ultrasound (GIIMUS) at University of São Paulo (USP). Ultrafast Ultrasound Imaging is a novel imaging technique that allows for acquisition of thousands of frames per second, and has several advantages over the conventional ultrasound, such as improved shear wave acquisition, which can benefit MMUS shear wave elastography. However, this technique has not been previously performed in GIIMUS group or national collaborator, but is highly explored by a research group from the Institute of Physics for Medicine Paris. Besides, this group has developed a technique called Ultrasound Localization Microscopy (ULM), that enables the acquisition of highly detailed maps of microvascular networks and flow dynamics. Therefore, this project aims to integrate all of these techniques to enhance performance in all of them. Our goal is to evaluate how ultrafast ultrasound imaging can enhance MMUS data acquisition and how MMUS, on the other way, can improve ULM by combining the microbubbles signal with the magnetic displacement generated in magnetic microbubbles.