Study on the selectivity of C-H bond oxidations directed by oximes

• Grant number: 24/22319-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2025
• End date: April 30, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Emílio Carlos de Lucca Júnior
• Grantee: Yasmin Nascimento Salmazo
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 24/11730-4 - Selective and late-stage functionalization of C-H bonds of complex molecules, AP.R

Abstract

Traditional methods for the construction and increase in complexity of organic molecules are mostly based on the manipulation of functional groups considered reactive, such as carbonyls, alcohols, amines, and halogenated groups. In contrast, nature routinely uses methods to directly oxidize C-H bonds, installing oxidized functionalities directly into the carbon skeleton of complex molecules without the need for pre-functionalization. Thus, the development of catalytic methods for the oxidation of C-H bonds presents a series of advantages, such as increased synthetic efficiency.Despite the advances achieved to date, for the oxidation of C-H bonds to reach its full potential, a series of challenges still need to be understood. Therefore, we propose to investigate, in this work, the selectivity in oxidation reactions catalyzed by palladium and directed by oximes of aliphatic and aromatic C-H bonds.