Development of Electroactive Devices Based on SERS Spectroscopy for Ultrasensitive Detection of Analytes

• Grant number: 25/03488-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: July 01, 2025
• End date: June 30, 2030
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Rômulo Augusto Ando
• Grantee: Ana Luiza Clivatti Yamanaka
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/11983-4 - Spectroscopy signal enhancement: nanomaterials, theory, and computer simulation, AP.TEM

Abstract

The detection of molecules at extremely low concentrations is a fundamental challenge in fields such as analytical chemistry, biomedicine, food safety, and environmental monitoring. In this context, Surface-Enhanced Raman Spectroscopy (SERS) has emerged as a powerful technique due to its ability to detect molecules at trace levels with high specificity and sensitivity. The SERS effect occurs when molecules interact with nanostructured metallic surfaces, resulting in a significant increase in the intensity of the Raman signal. Although the SERS technique offers numerous advantages, its practical application faces challenges related to reproducibility, stability, and portability. In this regard, electroactive devices have emerged as a promising solution to overcome such limitations, as they enable precise control of the chemical and electronic environment around the detection surface, optimizing the interaction between the target molecule and the hotspots responsible for the enhanced Raman scattering. This project aims to develop innovative electroactive devices based on tin oxide and indium/fluorine oxides (ITO/FTO) integrated with active SERS substrates, capable of providing a highly sensitive, selective, and robust platform for analyte detection. By exploring the synergy between electroactive devices and SERS spectroscopy, this work seeks to contribute significantly to the advancement of chemical sensors, paving the way for next-generation detection technologies. (AU)