IDPs/membrane interaction via scattering density profiles determined by SAXS combined with molecular dynamic simulation.

• Grant number: 25/07488-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2025
• End date: May 31, 2027
• Field of knowledge: Biological Sciences - Biophysics - Molecular Biophysics
• Principal Investigator: Rosangela Itri
• Grantee: Pedro Tendrih Sodré
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/07231-7 - Plasticity and functional modulation of intrinsically disordered proteins, AP.TEM

Abstract

In this project we will investigate the role of lipid composition of biological membranes (model membranes) under the action of intrinsically disordered proteins (amylin, alpha-synuclein). SAXS data will be acquired and analyzed by the chemical group scattering method (to be developed including the scattering of proteins in the software already developed by the research group) coupled to molecular dynamics simulation data. (AU)