Application of Proteomics and Bioinformatics in the Investigation of the Effects of Treatment with Docetaxel in LDE Nanoparticles and Physical Exercise on Urinary Bladder Carcinogenesis

• Grant number: 25/02445-7
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: September 10, 2025
• End date: March 09, 2026
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Giovana Rampazzo Teixeira
• Grantee: Victor Rogério Garcia Batista
• Supervisor: Vitor Samuel Leite Fernandes
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Institution abroad: Universidad Complutense de Madrid (UCM), Spain
• Associated to the scholarship: 23/13014-1 - DEVELOPMENT OF LIPID PARTICLE BIONANOTECHNOLOGY CARRYING DOCETAXEL CHEMOTHERAPY APPLIED TO URINARY BLADDER CARCINOGENESIS ASSOCIATED WITH AEROBIC PHYSICAL TRAINING, BP.MS

Abstract

To enhance the understanding of molecular mechanisms involved in urinary bladder carcinogenesis, we propose utilizing proteomics to analyze the impact of lipid-based nanoparticle drug carriers and aerobic physical training on tumor progression. The study focuses on characterizing protein expression patterns in the urinary bladder of rats undergoing chemically induced carcinogenesis. Techniques such as mass spectrometry will be employed to identify differentially expressed proteins related to oxidative stress, inflammation, and tumor suppression pathways. This project aims to build on prior findings, integrating proteomic data to explore therapeutic strategies combining docetaxel, LDE nanoparticles, and physical exercise. (AU)