INFLUENCES OF SEXUAL DIMORPHISM ON RESPIRATORY ALTERATIONS OBSERVED IN PARKINSON'S DISEASE

• Grant number: 25/11386-4
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2025
• End date: February 28, 2029
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ana Carolina Takakura Moreira
• Grantee: Tainá Oliveira Macedo
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 21/09768-5 - Influences of sexual dimorphism, inflammation and sleep on respiratory changes observed in Parkinson’s Disease, AP.TEM

Abstract

The influence of sex hormones on breathing is still not fully understood, especially in multifactorial pathological contexts such as Parkinson's disease (PD). Efforts should be made to study these phenomena, as they directly affect patient prognosis and survival, with the aim of developing the best possible treatments. In this context, the objectives proposed in this direct PhD project include:- Investigate the development of the 6-OHDA model in aged intact and ovariectomized female mice and compare it with males of the same age.- Assess the effect of ovariectomy on functional and neuroanatomical respiratory parameters in the 6-OHDA model.- Evaluate the effect of estrogen injection in ovariectomized females on functional and neuroanatomical respiratory parameters in the 6-OHDA model.