Evaluation of the Antinociceptive Effect of Topical Treatment with Hemopressin in Mice Subjected to an Experimental Model of Herpetic Neuralgia: Involvement of Voltage-Dependent Calcium Channels (Cav 2.2)

• Grant number: 25/04590-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2025
• End date: July 31, 2026
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Principal Investigator: Camila Squarzoni Dale
• Grantee: Thaís Pugliessa
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This project investigates neuropathic pain, a complex chronic condition that is often refractory to conventional treatments, focusing on a new therapeutic approach: hemopressin. Hemopressin is a peptide derived from hemoglobin that interacts with the endocannabinoid system, showing analgesic potential by reducing hyperalgesia and allodynia in animal models. The topical administration of hemopressin is particularly promising for the treatment of pain associated with herpes zoster and its chronic complication, postherpetic neuralgia. This project aims to examine the pathophysiology of herpes zoster, understanding the role of voltage-gated calcium channels (VGCCs) in synaptic transmission and pain modulation. Specifically, the Cav2.2 channels are the primary focus, as their modulation may offer new therapeutic pathways for pain control. Further research on hemopressin and its interactions with VGCCs could reveal innovative treatments for neuropathic pain and significantly improve patients' quality of life. (AU)