Formulation of a Lip Stick with Schinopsis brasiliensis Extract in an Oil-Continuous Emulsion for Actinic Cheilitis Management

• Grant number: 25/12882-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2025
• End date: August 31, 2026
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Lucas Amaral Machado
• Grantee: Yan Rafael Pontieri Malara
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Actinic Cheilitis (AC) is a chronic inflammatory condition caused by prolonged exposure to ultraviolet radiation, with a significant risk of progression to lip squamous cell carcinoma. Its prevalence is high among rural workers and populations chronically exposed to sunlight in both the Northeast and Southeast regions of Brazil, where adherence to effective lip photoprotection remains critically low. Schinopsis brasiliensis, a native species of the Caatinga biome also found in dry forest areas of Southeastern Brazil, exhibits anti-inflammatory, antioxidant, and photoprotective properties. However, its complex phytochemical composition poses challenges for direct incorporation into stable and effective topical formulations. This project proposes the development of a lip stick containing S. brasiliensis extract carried in an emulsion system with an external oily phase. This approach allows the incorporation of bioactive compounds with different polarity profiles, enhancing chemical stability and topical bioavailability. The formulation will be developed, characterized, and evaluated for physicochemical stability, encapsulation efficiency, pH, melting point, and organoleptic properties. By integrating pharmaceutical technology with the sustainable use of regional natural resources, this proposal aims to produce an innovative, safe, and accessible topical product with high potential for social and public health impact, especially in vulnerable populations of Brazil's Southeast and Northeast regions. (AU)