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Migration inhibitor factor and reactive oxigen species within nucleus tractus solitarius: role on cardiovascular control and hydroelectrolytic balance in SHR

Grant number: 10/09250-1
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2010
Effective date (End): December 31, 2012
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Eduardo Colombari
Grantee:André Henrique Freiria de Oliveira
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):11/20388-8 - The effects of MIF in the NTS upon microglia activation and inflammatory cytokines in SHR, BE.EP.PD


High blood pressure reaches 1/3 of west countries population increasing factors risk to coronary heart disease, myocardian infarction and congestive heart failure (eg, Many studies try to understand the hypertension causes and possible mechanism to treat it. Spontaneously hypertensive rats (SHR) it is a rat model that can be comparable with essential hypertension in humans. The central nervous system seems to plays an important role in the development and maintenance of hypertension. Among brain areas, we can highlight the role of the nucleus of the tract solitary (NTS), which is the primary site of visceral afferents. It has been demonstrated that commissrual NTS (commNTS) electrolytic lesions decrease mean arterial pressure (MAP) in SHR up to 10 days after the lesion and also increase water intake induced by hypotension in normotensive rats. Recently the macrophage inhibitory factor (MIF) has been shown to be an intracellular inhibitory regulator of actions of angiotensin II (ANG II), including in the central nervous system of the SHR. The contraregulatory effect of MIF on ANG II-induced responses seems to be due to the ROS scavenging properties of MIF. The effects of MIF in the NTS in the control of arterial pressure in normotensive and hypertensive animals is not known, as well the effects of MIF in the NTS on hydroelectrolytic balance control in SHR. Thus, our aim is to study the overexpression of MIF in NTS upon arterial blood pressure, heart function, oxidative stress in NTS, and also in hydroelectrolytic balance in SHR. Our preliminary data showed that MIF overexpression was able to decrease arterial blood pressure when compared with control (eGFP-injected rats) in both light period (130 ± 5 vs control 144 ± 3 mmHg) and dark period (130 ± 6 vs control 153 ± 4 mmHg). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FREIRIA-OLIVEIRA, ANDRE HENRIQUE; BLANCH, GRAZIELA TORRES; LI, HONGWEI; COLOMBARI, EDUARDO; ALMEIDA COLOMBARI, DEBORA SIMOES; SUMNERS, COLIN. Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs. Cardiovascular Research, v. 97, n. 1, p. 153-160, . (10/09250-1, 11/50770-1)

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