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Investigation of the in vitro antischistossomal, antileishmanial and trypanocidal activities of some tetrahydrofuran neolignans and dilactone lignans

Grant number: 08/09273-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2008
Effective date (End): November 30, 2009
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ademar Alves da Silva Filho
Grantee:Ana Carolina Gonzales Moraes
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

Lignans e neolignans have attracted much interest over the years on account of their broad range of biological activities. Previous biological activities showed that tetrahydrofuran and dibenzylbutirolactone lignans possess in vitro and in vivo antischistossomial activities. Considering the previous obtained results and as part of the Young Research Fapesp Project 06/60132-4, the aims of this project are: to obtain the tetrahydrofuran neolignans and dilactone lignans (1-3); to isolate, to purify and to identify the obtained compounds, as well as to evaluate the in vitro antischistossomial, antileishmanial and trypanocidal activities of these synthesized compounds. These compounds will be obtained by in vitro oxidative coupling using different phenylpropanoids. After synthesized, these compounds will be purified using several techniques, including chromatographic methods, and identified by spectroscopic analysis (p. ex. RMN 1H and 13C). All obtained compounds will be evaluated in the in vitro antischistossomial, antileishmanial and trypanocidal assays against, respectively, Schistosoma mansoni, Leishmania amazonensis and Trypanosoma cruzi.