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Frontal Lobe Avaliation of Patients with Juvenil Myoclonic Epilepsy using Proton Magnetic Resonance Spectroscopy

Grant number: 09/07097-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2009
Effective date (End): June 30, 2010
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:Maria Concepción García Otaduy
Grantee:Richard Geraldo Jaqueta Filho
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School, AP.CINAPCE.TEM

Abstract

Juvenil Myoclonic Epilepsy (JME) is a subtype of the group of Idiopathic Generalized Epilepsy that does not present apparent abnormalities on conventional Magnetic Resonance Imaging.However, proton Magnetic Resonance Spectroscopy (MRS) studies revealed conflicting metabolic alterations, especially regarding the decrease of marker N-acetyl aspartate (NAA) in the frontal lobe of patients.Considering this, this project aims to extend this study, using the technique of MRS with multi-voxel , which allows greater spatial extent of the analysis of the tissue involved, and applying a long time of echo (TE=135ms), which provides better quantification of metabolites .

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