Frontal Lobe Avaliation of Patients with Juvenil Myoclonic Epilepsy using Proton Magnetic Resonance Spectroscopy

• Grant number: 09/07097-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2009
• End date: June 30, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: Maria Concepción García Otaduy
• Grantee: Richard Geraldo Giachetti Filho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School, AP.CINAPCE.TEM

Abstract

Juvenil Myoclonic Epilepsy (JME) is a subtype of the group of Idiopathic Generalized Epilepsy that does not present apparent abnormalities on conventional Magnetic Resonance Imaging.However, proton Magnetic Resonance Spectroscopy (MRS) studies revealed conflicting metabolic alterations, especially regarding the decrease of marker N-acetyl aspartate (NAA) in the frontal lobe of patients.Considering this, this project aims to extend this study, using the technique of MRS with multi-voxel , which allows greater spatial extent of the analysis of the tissue involved, and applying a long time of echo (TE=135ms), which provides better quantification of metabolites .