Studies of the Heck arylation of allylamines with arenediazonium salts: Stereoselective synthesis of gama-Arylallylamines and the antifungal compound Naftifine.

• Grant number: 09/08546-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2009
• End date: July 31, 2010
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Carlos Roque Duarte Correia
• Grantee: Laís Ferreira Barbosa
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project proposes a systematic study of the Heck arylation of allylamines with arenediazonium salts. We aim to develop new methodologies that will overcome the current limitations found in traditional Heck protocols. Finally, this methodolgy will be applied to the synthesis of Naftifine, a synthetic allylamine used as a fungicide.