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Compounds with furanofurones and piranopirones frameworks from disacharides: synthetic studies

Grant number: 10/12701-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2010
Effective date (End): September 30, 2011
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Lúcia Helena Brito Baptistella
Grantee:Luiz Fernando Toneto Novaes
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action, AP.TEM

Abstract

This project refers to the exploration of synthetic methods for the transformation of lactose, an abundant natural disaccharide, in bicyclic lactones systems with furanofurone and furanopirone skeletons. These molecules present a great interest for biological activity studies, especially due to their structural similarity with other bicycles with known cytotoxic action, as exemplified by the styryl lactones. In this synthetic route, we want to explore stereo-and regioselective reactions.