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Development and characterization of porous biomaterial based of calcium phosphate with surface modified by the presence of PLA-co-PCL/PEG

Grant number: 07/08292-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2008
Effective date (End): March 31, 2010
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Ana Helena de Almeida Bressiani
Grantee:Christiane Ribeiro
Home Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

It is universally accepted that porous biomaterials of calcium phosphates introduced as grafting, repair of bone defects or as substrates for tissue engineering, induce an suitable response, proven by experimental evidence, which has reinforced its functionality. An alternative to making these ceramics, specifically, even more promising can be done aggregating better mechanical properties to porous ceramics, which have characteristics like: biocompatibility, appropriate porosity to osteoconduction and bioactivity. The fragility of ceramics can be offset by infiltration of a polymeric phase. The use of polymers and co-polymers based of e-caprolactone) (PCL), polyethylene glycol (PEG), polylactic acid(PLA) represents potential materials for this purpose, somehow, by the biocompatible, reabsorbable and hydrophilic characteristic obtained by the synergistic mixture. These speculations yet demand for further studies that can be sustained by the evaluation of the interaction between the phases and of biological and mechanical behavior of the composite ceramic/polymer. In this work, will be developed composites based on calcium phosphate, they will be characterized physically and mechanically, besides biologically by in vitro and in vivo essays, in the form of porous matrices infiltrated and covered by a thin layer of the polymeric blend PLA-co-PCL/PEG with reabsorbable and hydrophilic nature, maintaining the porous macrostructure of the matrix.