Deep anterior lamellar keratoplasty with Descemets baring. Experimental and clinical trial.

• Grant number: 09/09970-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2009
• End date: July 31, 2012
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: José Luiz Laus
• Grantee: Bianca da Costa Martins
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Deep corneal stromal diseases such as corneal dystrophy, keratoconus, corneal abscesses, keratomalacia, and iris prolapse are relatively common in humans and animals. Corneal transplantation may be useful to manage these abnormalities with penetrating keratoplasty (PK) one of the most widely used techniques for this purpose. Some stromal keratopathies have no involvement of the endothelium and Descemet's membrane such that their removal during PK could lead to increased corneal graft rejection and endothelial cell loss. Split thickness lamellar keratoplasties such as deep anterior lamellar keratoplasty (DALK) with and without Descemet's baring have been developed in human patients. Complete Descemet's membrane exposure is recommended as it minimizes post-surgical corneal opacification. Scientific studies of lamellar keratoplasties are few mainly related to the histology of the cornea after surgery. No studies of DALK have been studied in animals. This study will develop the technique of deep anterior lamellar keratoplasty with Descemet's exposure in animals, and compare it to penetrating keratoplasty in a clinical trial.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, BIANCA C.; BROOKS, DENNIS E.; PLUMMER, CARYN E.; SAMUELSON, DON A.; MANGAN, BRENDAN G.; LAUS, JOSE L.. Light microscopic evaluation and scanning electron microscopic analysis of horse eyes following deep anterior lamellar keratectomy. VETERINARY OPHTHALMOLOGY, v. 16, n. 1, p. 42-51, JUL 2013. (10/05454-1, 09/09970-7)

MARTINS, BIANCA C.; BROOKS, DENNIS E.; PLUMMER, CARYN E.; SAMUELSON, DON A.; MANGAN, BRENDAN G.; LAUS, JOSE L.. Light microscopic evaluation and scanning electron microscopic analysis of horse eyes following deep anterior lamellar keratectomy. VETERINARY OPHTHALMOLOGY, v. 16, p. 10-pg., 2013-07-01. (09/09970-7, 10/05454-1)