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Urolithiasis in children with acute lymphoblastic leukemia.

Grant number: 08/08311-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2009
Effective date (End): March 31, 2010
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Ricardo Jordão Duarte
Grantee:Mariane Gouvêa Monteiro de Camargo
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The objectives of this study are:1. check the incidence of urinary lithiasis in children treated for ALL in the Onco-hematology department of the Institute of Children's Hospital of the Medical School of the University of São Paulo;2. analyze the characteristics of clinical presentation of the stones (signs and symptoms), complications, need for interventional treatment for calculation of risk factors, morbidity and outcome of cases;3. check for correlation between the phase of chemotherapy and drugs used in the development of urinary lithiasis;4. Calculate the relative risk for urinary lithiasis in each phase of chemotherapy.This is a retrospective study involving 350 children with ALL, together from 1990 to 2008, with data obtained through analysis of medical records of children with ALL, enrolled in the service of Onco-Hematology of the Children's Institute and the Division of Urologic Clinic Hospital of the Medical School of the University of São Paulo. Will select the patients with urinary lithiasis who underwent treatment for ALL and will be evaluated the incidence of urolithiasis in this population.The patients will be assessed for the presence of gravel, time of treatment discovered the calculation (considering the phases of induction, maintenance with corticosteroids, without maintenance or outside of corticosteroid therapy), and demographic data used tests positive for diagnosis of lithiasis, occurrence complications as a result of calculations, developments of the case, need for interventional treatment, relationship with the phase of chemotherapy and related to the use of corticosteroids.Will be calculated the relative risk for developing renal lithiasis according to the stage of antineoplastic treatment.

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