Multi-locus candidate gene polymorphisms and risk of type 2 Diabetes Mellitus: population-based, prospective genetic analysis

• Grant number: 08/00676-6
• Support Opportunities: Scholarships abroad - Research
• Start date: April 01, 2008
• End date: August 31, 2008
• Field of knowledge: Health Sciences - Collective Health
• Principal Investigator: Alessandra Carvalho Goulart
• Grantee: Alessandra Carvalho Goulart
• Host Investigator: Kathryn M. Rexrode
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Institution abroad: Harvard University, Boston, United States

Abstract

Type 2 diabetes (T2D) is a complex disease characterized by insulin resistance and impaired pancreatic ²-cell function. In T2DM, a variety of environmental and genetic factors play a major role in the clinical expression of disease. The most frequent form of the disease is late onset T2DM, which may be characterized by a polygenic syndrome. Polymorphisms in candidate genes associated with glucose homeostasis, lipids metabolism, cardiovascular risk factors or pro-inflammatory cytokines may represent potential risk factors to T2DM. The aim of this study was to assess the relationship between a panel of well characterized genetic variants in 36 candidate genes and the incidence of type 2 diabetes mellitus. We evaluated a panel of 55 candidate genes polymorphisms in a total of 24,309 Caucasian women free of diabetes at baseline, who have participated of the Women's Health Study during median follow up of 10 years. Cox proportional-hazards models were constructed to compared the incidence of T2DM according to the different genotypes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PAGE-WILSON, GABRIELLE; GOULART, ALESSANDRA C.; REXRODE, KATHRYN M.. Interrelation Between Sex Hormones and Plasma Sex Hormone-Binding Globulin and Hemoglobin A1c in Healthy Postmenopausal Women. METABOLIC SYNDROME AND RELATED DISORDERS, v. 7, n. 3, p. 249-254, JUN 2009. (08/00676-6)

GOULART, ALESSANDRA C.; ZEE, ROBERT Y. L.; PRADHAN, ARUNA; REXRODE, KATHRYN M.. Associations of the Estrogen Receptors 1 and 2 Gene Polymorphisms With the Metabolic Syndrome in Women. METABOLIC SYNDROME AND RELATED DISORDERS, v. 7, n. 2, p. 111-117, APR 2009. (08/00676-6)